13CU

Crystal structure of covalent inhibitor 2-chloro-N-(3-((pyridin-2-ylthio)methyl)phenyl)acetamide bound to Ubiquitin C-terminal Hydrolase-L3

This is a non-PDB format compatible entry.

Summary for 13CU

• Entry DOI: 10.2210/pdb13cu/pdb
• Related: 1UCH
• Descriptor: Ubiquitin carboxyl-terminal hydrolase isozyme L3, N-(3-{[(pyridin-2-yl)sulfanyl]methyl}phenyl)propanamide (3 entities in total)
• Functional Keywords: uchl3, covalent inhibitor, chloroacetamide, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 81580.88

Authors

Patel, R.,Pannala, N.,Flaherty, D.,Das, C. (deposition date: 2026-04-30, release date: 2026-08-26)

• Primary citation: Beeralingappa, N.C.,Lu, M.,Patel, R.,Pannala, N.,Dhiman, A.,Heil, B.N.,Imhoff, R.D.,Smith, E.G.,Bahler, M.B.,Marsden, H.L.,Allen-Petersen, B.L.,Wendt, M.K.,Das, C.,Flaherty, D.P.; Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3; Biorxiv, 2026; DOI: 10.64898/2026.05.26.727856

Experimental method

X-RAY DIFFRACTION (1.95 Å)