12UV

The AAV2 capsid in complex with IgA-Fab#3-4

This is a non-PDB format compatible entry.

Summary for 12UV

• Entry DOI: 10.2210/pdb12uv/pdb
• EMDB information: 76773
• Descriptor: Capsid protein VP1, IgA-Fab3-4 heavy chain, IgA-Fab3-4 light chain (3 entities in total)
• Functional Keywords: aav, gene therapy, antibody, cryo-em, iga, neutralization, virus
• Biological source: adeno-associated virus 2; More
• Total number of polymer chains: 180
• Total formula weight: 5112995.46

Authors

Zachery, J.,Mietzsch, M.,McKenna, R. (deposition date: 2026-04-20, release date: 2026-09-30)

• Primary citation: Logan, G.J.,Khandekar, N.,Hall, B.,Zachery, J.,Mandwie, M.,Hsi-Bell, J.,Huang, A.,Vyas, K.,Anderson, D.,Knight, M.,Farrar, M.A.,Lisowski, L.,Reed, J.H.,Mietzsch, M.,McKenna, R.,Alexander, I.E.; Broadly cross-reactive anti-capsid IgA is an overlooked antibody 1 barrier in AAV2 mediated gene transfer; Nat Commun, 2026

Experimental method

ELECTRON MICROSCOPY (2.68 Å)