12LU

LSD1-CoREST in complex with GSK-LSD1 and peptide PRSALV

Summary for 12LU

• Entry DOI: 10.2210/pdb12lu/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, PRSAL, ... (4 entities in total)
• Functional Keywords: epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, flavoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 113073.87

Authors

Caroli, J.,Mattevi, A. (deposition date: 2026-04-12, release date: 2026-11-11)

• Primary citation: Liu, C.,Yost, K.,Kwok, H.S.,Caroli, J.,Waterbury, A.L.,Gankhuyag, N.,Zhang, O.,Harry, S.A.,Hansen, T.N.,Roh, H.,Furui, A.,Mattevi, A.,Liau, B.B.; Covalent Chemical Rescue of a Transcription Factor-Corepressor Complex; Acs Cent.Sci., 2026; DOI: 10.1021/acscentsci.6c01320

Experimental method

X-RAY DIFFRACTION (3.2 Å)