12GR

HDAC1-MTA1 in complex with TICA (5-(Thiophen-2-yl)Isoxazole-3-Carboxylic Acid), the hydrolysis product of WNA1 by HDAC1

This is a non-PDB format compatible entry.

Summary for 12GR

• Entry DOI: 10.2210/pdb12gr/pdb
• Descriptor: Metastasis-associated protein MTA1, Histone deacetylase 1, SULFATE ION, ... (9 entities in total)
• Functional Keywords: hdac1, mta1, wnt activator, nurd, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 78350.70

Authors

Zhou, Z.,Chen, Z. (deposition date: 2026-04-04, release date: 2026-11-11)

• Primary citation: Zhou, Z.,Chen, Z.; A conformation-sensitive product inhibitor of HDAC1/2 potentiates WNT signaling; Nat.Chem.Biol., 2026; DOI: 10.1038/s41589-026-02385

Experimental method

X-RAY DIFFRACTION (2.3 Å)