11SI

Covalent stabilizer compound 15A for the interaction between 14-3-3 sigma and Estrogen receptor-alpha peptide

This is a non-PDB format compatible entry.

Summary for 11SI

• Entry DOI: 10.2210/pdb11si/pdb
• Descriptor: 14-3-3 protein sigma, Estrogen receptor, (2S)-2-(1-acetylpiperidin-4-yl)-1-[(3R,5S)-4-(chloroacetyl)-3,5-dimethylpiperazin-1-yl]-2-(4-chlorophenyl)ethan-1-one, ... (4 entities in total)
• Functional Keywords: 14-3-3, adapter, phosphoserine, phosphothreonine, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 60655.20

Authors

Knapp, M.S.,Tang, J.Y. (deposition date: 2026-03-11, release date: 2026-08-26, Last modification date: 2026-09-02)

• Primary citation: Rama, J.,Skepper, C.K.; Covalent stabilizers of the interaction between 14-3-3 and Estrogen receptor-alpha; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)