11RM

Cryo-EM structure of human exportin-1 conjugated with FR-027*

This is a non-PDB format compatible entry.

Summary for 11RM

• Entry DOI: 10.2210/pdb11rm/pdb
• EMDB information: 75979
• Descriptor: Exportin-1, 1-methyl-4-nitro-1H-imidazole (2 entities in total)
• Functional Keywords: nuclear transport, inhibitor, protein transport
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 123789.58

Authors

Wing, C.E.,Fung, H.Y.J.,Chook, Y.M. (deposition date: 2026-03-10, release date: 2026-07-29)

• Primary citation: Van Hauwenhuyse, J.,Reniers, F.,Persoons, L.,Noppen, S.,Wing, C.E.,Niesman, A.B.,Fung, H.Y.J.,Vanstreels, E.,Jacquemyn, M.,Boel, E.,Vankerckhoven, A.,Berckmans, Y.,Kwanten, B.,Coosemans, A.,Van den Mooter, G.,Chook, Y.M.,Dehaen, W.,Daelemans, D.; Preclinical characterization of a reversible XPO1 inhibitor for cancer therapy; Nat Commun, 2026; DOI: 10.1038/s41467-026-75741-y

Experimental method

ELECTRON MICROSCOPY (2.95 Å)