11ES

Structure of GDP-bound KRAS-G12C/H95Q, a Switch-II Pocket Inhibitor Resistance Mutant

Summary for 11ES

Entry DOI	10.2210/pdb11es/pdb
Descriptor	Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	ras, oncogenic mutation, drug resistance, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	19816.32
Authors	Whitley, M.J.,Simanshu, D.K. (deposition date: 2026-02-19, release date: 2026-10-07)
Primary citation	Whitley, M.J.,Dyba, M.,Chakrabarti, M.,Smith, B.P.,Chan, A.H.,Denson, J.P.,Messing, S.A.,Lin, K.,Cornilescu, G.,Balius, T.E.,Nissley, D.V.,McCormick, F.,Maciag, A.E.,Simanshu, D.K. Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS Nat Commun, 2026 Cited by DOI: 10.1038/s41467-026-78133-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation