11CI

Staphylococcus aureus-specific lysin L1-3 (LysM-CHAP) covalently complexed to Pep1a-CMK substrate mimic

This is a non-PDB format compatible entry.

Summary for 11CI

• Entry DOI: 10.2210/pdb11ci/pdb
• Descriptor: Probable cell wall hydrolase LytN, N~2~-acetyl-N~6~-{(4M)-3-carboxy-4-[(10aR)-6-hydroxy-3-oxo-4,10a-dihydro-3H-xanthen-9-yl]benzene-1-carbonyl}-D-lysyl-L-alanyl-D-alpha-glutaminyl-N-[(2R)-3-oxobutan-2-yl]-L-lysinamide, SODIUM ION, ... (4 entities in total)
• Functional Keywords: lysin, chap, enzyme, peptidoglycan, bacteria, phage, lysm, endopeptidase, inhibitor, substrate, hydrolase
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 25088.00

Authors

Miller, H.A.,Palowitch, G.M.,Dulberger, C.L. (deposition date: 2026-02-17, release date: 2026-05-06)

• Primary citation: Badarau, A.,Bauer, B.,Visram, Z.,Qiao, R.,Majoros-Hashempour, A.,Sollner, J.,Durica-Mitic, S.,Dunne, O.M.,Kluj, R.,Kestemont, D.,Kieninger, A.K.,Kulig, M.,Berdaguer, R.,Schwebs, T.,Zerbs, M.,Czermak, P.,von Freyberg, M.,Schmidt, J.,Schmidberger, L.,Mayer, D.,Protano, M.,Miller, H.A.,Palowitch, G.M.,Dulberger, C.L.,Massaro, M.,Ivanisenko, N.,Jacomet, H.,Ngatcha Bakoue, D.,Oteri, F.,Sela, G.,Corsini, L.; Multi-dimensional optimization of a lysin towards a ribolysin against life-threatening S. aureus infections: Fc-LysM-CHAP and its strong synergy with standard of care antibiotics; Biorxiv, 2026; DOI: 10.64898/2026.04.27.720530

Experimental method

X-RAY DIFFRACTION (2.83 Å)