11CG

CHAP domain of Staphylococcus aureus-specific lysin L2

Summary for 11CG

Entry DOI	10.2210/pdb11cg/pdb
Descriptor	CHAP domain of lysin L2, SODIUM ION, THIOCYANATE ION, ... (4 entities in total)
Functional Keywords	lysin, chap, enzyme, peptidoglycan, bacteria, phage, lysm, endopeptidase, hydrolase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	16905.54
Authors	Miller, H.A.,Palowitch, G.M.,Dulberger, C.L. (deposition date: 2026-02-17, release date: 2026-05-06)
Primary citation	Badarau, A.,Bauer, B.,Visram, Z.,Qiao, R.,Majoros-Hashempour, A.,Sollner, J.,Durica-Mitic, S.,Dunne, O.M.,Kluj, R.,Kestemont, D.,Kieninger, A.K.,Kulig, M.,Berdaguer, R.,Schwebs, T.,Zerbs, M.,Czermak, P.,von Freyberg, M.,Schmidt, J.,Schmidberger, L.,Mayer, D.,Protano, M.,Miller, H.A.,Palowitch, G.M.,Dulberger, C.L.,Massaro, M.,Ivanisenko, N.,Jacomet, H.,Ngatcha Bakoue, D.,Oteri, F.,Sela, G.,Corsini, L. Multi-dimensional optimization of a lysin towards a ribolysin against life-threatening S. aureus infections: Fc-LysM-CHAP and its strong synergy with standard of care antibiotics Biorxiv, 2026 Cited by DOI: 10.64898/2026.04.27.720530 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation