11AM

Cryo-EM structure of a bovine CLC-K S68N/R355K chloride channel with 100 mM Ca2+

Summary for 11AM

Entry DOI	10.2210/pdb11am/pdb
EMDB information	75590
Descriptor	Chloride voltage-gated channel Ka, CHLORIDE ION (2 entities in total)
Functional Keywords	chloride channel, membrane protein, transport protein
Biological source	Bos taurus (domestic cattle)
Total number of polymer chains	2
Total formula weight	147111.89
Authors	Chien, C.-T.,Chiu, W.,Maduke, M. (deposition date: 2026-02-13, release date: 2026-09-09)
Primary citation	Chien, C.T.,Sobecks-Doherty, B.L.,Powers, A.S.,Das, A.,Kreiter, J.,Barry, C.N.,Chen, M.,Hinman, A.,Petrakian, C.F.,Williams, B.,Wood, C.A.P.,Xu, M.,Dror, R.O.,Chiu, W.,Maduke, M. Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels Proc.Natl.Acad.Sci.USA, 123:-, 2026 Cited by DOI: 10.1073/pnas.2605886123 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation