10ZP

Cryo-EM structure of TccCas13a-crRNA-target RNA ternary complex

Summary for 10ZP

• Entry DOI: 10.2210/pdb10zp/pdb
• EMDB information: 75570
• Descriptor: CRISPR-associated endoribonuclease Cas13a, RNA (95-MER) (2 entities in total)
• Functional Keywords: cas13a, ternary complex, thermostability, structure-guided engineering, rna binding protein
• Biological source: Thermoclostridium caenicola; More
• Total number of polymer chains: 2
• Total formula weight: 173865.61

Authors

Oladeji, S.J.,Gao, Y. (deposition date: 2026-02-13, release date: 2026-10-07)

• Primary citation: Oladeji, S.J.,Gonzalez, D.H.,Deng, X.,You, Z.,Zhang, Y.,Golla, D.A.,Smith, J.,Zhang, Y.,Gao, X.,Lillehoj, P.B.,Gao, Y.; Structural basis and rational engineering of a thermophilic Cas13a for robust RNA detection.; Cell Chem Biol, 34:1-14, 2026; DOI: 10.1016/j.chembiol.2026.09.012

Experimental method

ELECTRON MICROSCOPY (3.13 Å)