10PX

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with benzoxaborole derivative of azithromycin (AZI-BB2), mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution

This is a non-PDB format compatible entry.

Summary for 10PX

• Entry DOI: 10.2210/pdb10px/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (62 entities in total)
• Functional Keywords: macrolides, azithromycin, benzoxaboroles, ribosome, translation, inhibition, antibiotic, drug resistance
• Biological source: Escherichia coli; More
• Total number of polymer chains: 112
• Total formula weight: 4572995.02

Authors

Chen, C.-W.,Volynkina, I.A.,Bortyazh, M.O.,Tereshchenkov, A.G.,Karakchieva, A.O.,Lukianov, D.A.,Komarova, E.S.,Tupikin, A.E.,Skvortsov, D.A.,Tevyashova, A.N.,Tikhomirov, A.S.,Tashlitsky, V.N.,Kabilov, M.R.,Shchekotikhin, A.E.,Dontsova, O.A.,Sergiev, P.V.,Polikanov, Y.S. (deposition date: 2026-02-01, release date: 2026-03-11)

• Primary citation: Volynkina, I.A.,Bortyazh, M.O.,Chen, C.-W.,Tereshchenkov, A.G.,Karakchieva, A.O.,Lukianov, D.A.,Komarova, E.S.,Tupikin, A.E.,Skvortsov, D.A.,Tevyashova, A.N.,Tikhomirov, A.S.,Tashlitsky, V.N.,Kabilov, M.R.,Shchekotikhin, A.E.,Dontsova, O.A.,Polikanov, Y.S.,Sergiev, P.V.; Benzoxaborole-modified azithromycins inhibit translation without inducing ermC expression; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)