10HM

Trypanosoma brucei CLK1 kinase domain in complex with a covalent Amidobenzimidazole (AB4) inhibitor

This is a non-PDB format compatible entry.

Summary for 10HM

• Entry DOI: 10.2210/pdb10hm/pdb
• Descriptor: Protein kinase, putative, %{N}-(1-{(3%{R})-1-[4-(dimethylamino)butanoyl]azepan-3-yl}-4,6-difluoro-1%{H}-1,3-benzimidazol-2-yl)-5-fluoropyridine-3-carboxamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: clk1 kkt10, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Trypanosoma brucei brucei TREU927
• Total number of polymer chains: 16
• Total formula weight: 699461.29

Authors

Mamo, M. (deposition date: 2026-01-20, release date: 2026-06-17)

• Primary citation: Mamo, M.; Trypanosoma brucei CLK1 kinase domain in complex with a covalent Amidobenzimidazole (AB4) inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)