10BT

X-ray Crystal Structure of A High-Affinity Monoclonal Antibody Sequesters Xylazine

This is a non-PDB format compatible entry.

Summary for 10BT

• Entry DOI: 10.2210/pdb10bt/pdb
• Descriptor: Antibody Heavy Chain, Antibody Light Chain, N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine, ... (5 entities in total)
• Functional Keywords: monoclonal antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 197273.62

Authors

Shi, K.,Moller, N.,Aihara, H. (deposition date: 2026-01-10, release date: 2026-06-10)

• Primary citation: Kang, J.,Xu, R.,Lee, S.,Luengas, D.,Kim, C.M.,Marecki, C.,Gallant, J.,Moeller, N.,Shi, K.,Jahan, R.,Hicks, D.,Runyon, S.,Aihara, H.,Pravetoni, M.; Discovery, Structural Characterization, and Preclinical Evaluation of Monoclonal Antibodies against Xylazine Poisoning; Acs Pharmacol Transl Sci, 2026; DOI: 10.1021/acsptsci.6c00117

Experimental method

X-RAY DIFFRACTION (1.99 Å)