10GD

The eukaryotic translation initiation factor 2B from Homo sapiens with a L179V mutation in the delta subunit bound to ISRIB

Summary for 10GD

• Entry DOI: 10.2210/pdb10gd/pdb
• EMDB information: 75147
• Descriptor: Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF2B subunit delta, ... (9 entities in total)
• Functional Keywords: complex, gef, translation, guanine nucleotide exchange factor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 531417.89

Authors

Dalwadi, U.,Boone, M.,Croll, T.I.,Laughlin, T.G.,Frost, A.,Walter, P. (deposition date: 2026-01-19, release date: 2026-10-28)

• Primary citation: Boone, M.,Dalwadi, U.,Deal, A.,Zhu, P.J.,Croll, T.I.,Yamazaki, M.,Prescott, K.,Minopoli, R.,Biscocho, I.,Wang, J.,Lee, D.J.,Arthur, C.P.,Laughlin, T.G.,Zhou, H.,Klope, M.T.,Egea, P.F.,Schoof, M.,Lawrence, R.,Renslo, A.R.,Costa-Mattioli, M.,Frost, A.,Walter, P.; Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer; Biorxiv, 2026; DOI: 10.64898/2026.02.04.700910

Experimental method

ELECTRON MICROSCOPY (2.1 Å)