9ZZO
MP1104-bound Kappa Opioid Receptor in complex with beta-arrestin1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Nanobody 32 | polymer | 124 | 13665.1 | 1 | Lama glama (llama) | ||
| 2 | B (C) | Isoform 1B of Beta-arrestin-1 | polymer | 387 | 43358.2 | 1 | UniProt (P49407) | Homo sapiens (human) | Arrestin beta-1,Non-visual arrestin-2 |
| 3 | C (A) | Kappa-type opioid receptor,Vasopressin V2 receptor | polymer | 341 | 38723.1 | 1 | UniProt (P41145) UniProt (P30518) | Homo sapiens (human) | K-OR-1,KOR-1,V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
| 4 | D (H) | Fab30 heavy chain | polymer | 241 | 25754.6 | 1 | synthetic construct | ||
| 5 | E (L) | Fab30 light chain | polymer | 215 | 23435.1 | 1 | synthetic construct | ||
| 6 | F (C) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 1 | Chemie (PIO) | |||
| 7 | G (A) | N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide | non-polymer | 554.4 | 1 | Chemie (CVV) PubChem (131955138) |
Sequence modifications
C: 2 - 385 (UniProt: P49407)
A: 54 - 363 (UniProt: P41145)
A: 364 - 392 (UniProt: P30518)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Ala 59 | Cys 59 | conflict |
| Ser 125 | Cys 125 | conflict |
| Ile 140 | Cys 140 | conflict |
| Val 150 | Cys 150 | conflict |
| Glu 169 | Arg 169 | conflict |
| Val 242 | Cys 242 | conflict |
| Val 251 | Cys 251 | conflict |
| Ser 269 | Cys 269 | conflict |
| Ala 378 | Ile 378 | conflict |
| Ala 379 | Val 379 | conflict |
| Ala 380 | Phe 380 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 135 | Ile 135 | conflict |
| Cys 324 | Ser 324 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 393 | - | expression tag |
| Gly 394 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 144936.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1301.0 | |
| All* | Total formula weight | 146237.1 |
