9ZVX
Structural insights into the exosite-mediated activation of Factor IX by Factor XIa using cryoEM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor XIa heavy chain | polymer | 369 | 41262.1 | 1 | UniProt (P03951) | Homo sapiens (human) | |
| 2 | B (B) | Coagulation factor XIa light chain | polymer | 236 | 26686.4 | 1 | UniProt (P03951) | Homo sapiens (human) | |
| 3 | C (C) | Coagulation factor IXa light chain | polymer | 145 | 17033.4 | 1 | UniProt (P00740) | Homo sapiens (human) | |
| 4 | D (D) | Coagulation factor IXa heavy chain | polymer | 235 | 26190.8 | 1 | UniProt (P00740) | Homo sapiens (human) | Christmas factor,Plasma thromboplastin component,PTC |
| 5 | E, F, G, H (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) PubChem (24139) | |||
| 6 | I, J, K, L, M... (C) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) PubChem (271) |
Sequence modifications
B: 370 - 605 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ala 557 | Ser 575 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 111172.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1205.5 | |
| All* | Total formula weight | 112378.1 |
