9ZU4

Crystal structure of BRD9 bromodomain bound to BZ2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Bromodomain-containing protein 9	polymer	129	14989.2	1	UniProt (Q9H8M2) Pfam (PF00439)	Homo sapiens (human)	Rhabdomyosarcoma antigen MU-RMS-40.8
2	B (A)	6-[4-(2-aminoethyl)anilino]-5-chloro-3-methylpyrimidin-4(3H)-one	non-polymer		278.7	1	Chemie (XHK) PubChem (171390562)
3	C (A)	water	water		18.0	159	Chemie (HOH)

Sequence modifications

A: 134 - 239 (UniProt: Q9H8M2)

PDB	External Database	Details
Met 111	-	initiating methionine
Gly 112	-	expression tag
Ser 113	-	expression tag
Ser 114	-	expression tag
His 115	-	expression tag
His 116	-	expression tag
His 117	-	expression tag
His 118	-	expression tag
His 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag
His 122	-	expression tag
His 123	-	expression tag
Ser 124	-	expression tag
Ser 125	-	expression tag
Gly 126	-	expression tag
Glu 127	-	expression tag
Asn 128	-	expression tag
Leu 129	-	expression tag
Tyr 130	-	expression tag
Phe 131	-	expression tag
Gln 132	-	expression tag
Gly 133	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	14989.2
Non-Polymers*	Number of molecules	1
	Total formula weight	278.7
All*	Total formula weight	15267.9

*Water molecules are not included.