9ZN9

Structure of rabbit RyR1 complexed with FKBP12.6, calmodulin, ATP, 4-chloro-m-cresol, and caffeine

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (E, F, G, H)	Peptidyl-prolyl cis-trans isomerase FKBP1B	polymer	107	11667.3	4	UniProt (P68106) Pfam (PF00254)	Homo sapiens (human)	PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12
2	E, F, G, H (I, J, K, L)	Calmodulin-1	polymer	148	16790.4	4	UniProt (P0DP23) Pfam (PF13499)	Homo sapiens (human)
3	I, J, K, L (A, C, D, B)	Ryanodine receptor 1	polymer	5037	565908.6	4	UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119)	Oryctolagus cuniculus (rabbit)	RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor
4	BA, EA, FA, IA, KA... (C, D, A, B)	4-CHLORO-3-METHYLPHENOL	non-polymer		142.6	16	Chemie (43M) PubChem (1732)
5	GA, O, PA, X (D, A, B, C)	CAFFEINE	non-polymer		194.2	4	Chemie (CFF) PubChem (2519)
6	HA, P, QA, Y (D, A, B, C)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA) PubChem (271)
7	AA, CA, JA, LA, R... (C, D, A, B)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	8	Chemie (ATP)
8	DA, MA, U, VA (C, D, A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN) PubChem (32051)
9	AB, BB, CB, DB, EB... (I, J, K, L, A...)	water	water		18.0	2923	Chemie (HOH)

Sequence modifications

I, J, K, L: 0 - 146 (UniProt: P0DP23)

PDB	External Database	Details
His -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	2377465.5
Non-Polymers*	Number of molecules	36
	Total formula weight	7537.5
All*	Total formula weight	2385002.9

*Water molecules are not included.