9ZLJ
Crystal structure of BTK kinase domain bound to compound YS1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 278 | 32245.0 | 1 | UniProt (P35991) Pfam (PF07714) | Mus musculus (house mouse) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase,Kinase EMB |
| 2 | B (A) | N-{(1r,4r)-4-[2-(4-chlorophenoxy)acetamido]cyclohexyl}-N-[2-(4-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]propanamide | non-polymer | 497.0 | 1 | Chemie (A1C20) | |||
| 3 | C (A) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 4 | D (A) | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence modifications
A: 382 - 659 (UniProt: P35991)
| PDB | External Database | Details |
|---|---|---|
| Pro 617 | Tyr 617 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32245.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 566.1 | |
| All* | Total formula weight | 32811.1 |
