9ZLE

Crystal structure of DCAF1 in complex with SDIPTAC C8

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	DDB1- and CUL4-associated factor 1	polymer	314	35535.9	6	UniProt (Q9Y4B6)	Homo sapiens (human)	HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein
2	G, H, J, K (A, C, E, F)	(4P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide	non-polymer		438.3	4	Chemie (A1C24)
3	I (D)	(4P,4'P)-5,5'-[(1E,33E)-3,32-dioxo-7,10,13,16,19,22,25,28-octaoxa-4,31-diazatetratriaconta-1,33-diene-1,34-diyl]bis{N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide}	non-polymer		1393.1	1	Chemie (A1C25)
4	L, M, N, O, P... (A, B, C, D, E...)	water	water		18.0	225	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1077 - 1390 (UniProt: Q9Y4B6)

PDB	External Database	Details
Ala 1077	Phe 1077	engineered mutation
Ala 1079	Arg 1079	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	213215.4
Non-Polymers*	Number of molecules	5
	Total formula weight	3146.1
All*	Total formula weight	216361.5

*Water molecules are not included.