9ZKU
The LBD-TMD structure of native mouse AMPAR with 3 TARPs 1 CNIH and PRRT1/SynDIG4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Glutamate receptor 1 | polymer | 500 | 55260.2 | 2 | UniProt (P23818) Pfam (PF10613) Pfam (PF00060) | Mus musculus (house mouse) | GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1 |
| 2 | B, D (B, D) | Glutamate receptor 2 | polymer | 467 | 52118.8 | 2 | UniProt (C9K0Z0) | Mus musculus (house mouse) | |
| 3 | E (E) | Protein cornichon homolog 2 | polymer | 160 | 18948.4 | 1 | UniProt (O35089) Pfam (PF03311) | Mus musculus (house mouse) | CNIH-2,Cornichon family AMPA receptor auxiliary protein 2,Cornichon-like protein |
| 4 | F (F) | Voltage-dependent calcium channel gamma-2 subunit | polymer | 323 | 35938.7 | 1 | UniProt (O88602) Pfam (PF00822) | Mus musculus (house mouse) | Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2 |
| 5 | G, H (G, H) | Voltage-dependent calcium channel gamma-8 subunit | polymer | 423 | 43502.9 | 2 | UniProt (Q8VHW2) Pfam (PF00822) | Mus musculus (house mouse) | Neuronal voltage-gated calcium channel gamma-8 subunit,Transmembrane AMPAR regulatory protein gamma-8,TARP gamma-8 |
| 6 | I (M) | Proline-rich transmembrane protein 1 | polymer | 306 | 31416.8 | 1 | UniProt (O35449) Pfam (PF04505) | Mus musculus (house mouse) | Dispanin subfamily D member 1,DSPD1,Synapse differentiation-induced protein 4,SynDIG4 |
| 7 | J, L, P, S (A, B, C, D) | PALMITIC ACID | non-polymer | 256.4 | 4 | Chemie (PLM) PubChem (985) | |||
| 8 | K, M, O, Q, R... (A, B, C, D) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 7 | Chemie (OLC) PubChem (11451146) | |||
| 9 | N (B) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 1 | Chemie (POV) |
Sequence modifications
B, D: 396 - 862 (UniProt: C9K0Z0)
| PDB | External Database | Details |
|---|---|---|
| Arg 743 | Gly 764 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 388067.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4281.6 | |
| All* | Total formula weight | 392349.3 |
