9ZBK

mTORC2 in complex with Akt1

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine/threonine-protein kinase mTOR	polymer	2470	280530.1	1	UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF23593) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260)	Homo sapiens (human)	FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,Tyrosine-protein kinase mTOR
2	B (B)	Target of rapamycin complex subunit LST8	polymer	318	35152.2	1	UniProt (Q9BVC4) Pfam (PF00400)	Homo sapiens (human)	TORC subunit LST8,G protein beta subunit-like,Gable,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8
3	C (C)	Rapamycin-insensitive companion of mTOR	polymer	1670	188389.5	1	UniProt (Q6R327) Pfam (PF14664) Pfam (PF14666) Pfam (PF14663) Pfam (PF14668) Pfam (PF14665)	Homo sapiens (human)	AVO3 homolog,hAVO3
4	D (D)	Target of rapamycin complex 2 subunit MAPKAP1	polymer	269	30466.4	1	UniProt (Q9BPZ7) Pfam (PF05422) Pfam (PF16978)	Homo sapiens (human)	TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,SAPK-interacting protein 1,mSIN1
5	E (E)	RAC-alpha serine/threonine-protein kinase	polymer	338	39206.9	1	UniProt (P31749) Pfam (PF00069) Pfam (PF00433)	Homo sapiens (human)	Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha
6	F (C)	ZINC ION	non-polymer		65.4	1	Chemie (ZN) PubChem (32051)
7	G (E)	(1M,9M)-1-{4-[4-(prop-2-enoyl)piperazin-1-yl]-3-(trifluoromethyl)phenyl}-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one	non-polymer		605.6	1	Chemie (A1AID)	Homo sapiens (human)	Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha

Sequence modifications

D: 1 - 269 (UniProt: Q9BPZ7)

PDB	External Database	Details
Thr 74	Ser 74	conflict
Ser 135	Ile 135	conflict
Lys 267	-	insertion

E: 141 - 478 (UniProt: P31749)

PDB	External Database	Details
Cys 473	Ser 473	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	573745.0
Non-Polymers*	Number of molecules	2
	Total formula weight	671.0
All*	Total formula weight	574416.0

*Water molecules are not included.