9ZBJ
Cryo-EM structure of human apo mTORC2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase mTOR | polymer | 2347 | 266891.9 | 1 | UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF23593) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) | Homo sapiens (human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,Tyrosine-protein kinase mTOR |
| 2 | B (B) | Target of rapamycin complex subunit LST8 | polymer | 317 | 35053.1 | 1 | UniProt (Q9BVC4) Pfam (PF00400) | Homo sapiens (human) | TORC subunit LST8,G protein beta subunit-like,Gable,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8 |
| 3 | C (C) | Rapamycin-insensitive companion of mTOR | polymer | 1672 | 188647.7 | 1 | UniProt (Q6R327) Pfam (PF14664) Pfam (PF14666) Pfam (PF14663) Pfam (PF14668) Pfam (PF14665) | Homo sapiens (human) | AVO3 homolog,hAVO3 |
| 4 | D (D) | Target of rapamycin complex 2 subunit MAPKAP1 | polymer | 148 | 16921.1 | 1 | UniProt (Q9BPZ7) Pfam (PF05422) | Homo sapiens (human) | TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,SAPK-interacting protein 1,mSIN1 |
| 5 | E (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 507513.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 507579.2 |
