9ZB8
Crystal Structure of Human GGPPS Bound to Selective Inhibitor CML-07-119
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Geranylgeranyl pyrophosphate synthase | polymer | 301 | 34972.9 | 12 | UniProt (O95749) | Homo sapiens (human) | GGPP synthase,GGPPSase,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Farnesyltranstransferase,Geranylgeranyl diphosphate synthase,Geranyltranstransferase |
| 2 | AB, CA, EB, GA, KA... (K, E, L, F, G...) | {[(2-{3-[(3-fluoro-4-methoxyphenyl)carbamoyl]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid) | non-polymer | 568.4 | 12 | Chemie (A1C1E) | |||
| 3 | AA, BA, BB, CB, DA... (D, K, E, L, F...) | MAGNESIUM ION | non-polymer | 24.3 | 36 | Chemie (MG) PubChem (888) | |||
| 4 | IB, JB, KB, LB, MB... (A, B, C, D, E...) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 300 (UniProt: O95749)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 419674.6 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 7695.9 | |
| All* | Total formula weight | 427370.5 |
