9ZB5

Cryo-EM structure of the parainfluenza virus hemagglutinin-neuraminidase protein in complex with the human antibodies PIV3HN-05 and PIV3HN-13

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	PIV3HN-05 heavy chain	polymer	249	26359.6	2		Homo sapiens
2	C, F (E, H)	PIV3HN-05 light chain	polymer	217	22877.2	2		Homo sapiens
3	D, H (F, J)	Hemagglutinin-neuraminidase	polymer	461	51625.5	2	UniProt (Q81080)	Human respirovirus 3
4	E, I (G, M)	PIV3HN-13 heavy chain	polymer	240	25321.3	2		Homo sapiens
5	G, J (I, N)	PIV3HN-13 light chain	polymer	218	23785.4	2		Homo sapiens
6	K, L (K, L)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose-(5-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		773.7	2
7	M, N (F, J)	alpha-L-fucopyranose	non-polymer		164.2	2	Chemie (FUC) PubChem (439554)

Sequence modifications

F, J: 14 - 461 (UniProt: Q81080)

PDB	External Database	Details
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
Ser 7	-	expression tag
Leu 8	-	expression tag
Val 9	-	expression tag
Pro 10	-	expression tag
Arg 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	299937.9
Branched	Number of molecules	2
	Total formula weight	1547.5
Non-Polymers*	Number of molecules	2
	Total formula weight	328.3
All*	Total formula weight	301813.7

*Water molecules are not included.