9Z9F
Structure of FabS1CE2_ER-2a in complex with the extracellular region of EGFR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | heavy chain | polymer | 237 | 25513.5 | 2 | Homo sapiens | ||
| 2 | B, D (B, D) | light chain | polymer | 212 | 23198.7 | 2 | Homo sapiens | ||
| 3 | E, F (G, K) | Epidermal growth factor receptor | polymer | 625 | 69133.8 | 2 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 4 | G (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | H, I (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) PubChem (8117) | |||
| 6 | J, K, O, P, Q... (A, B, D, G) | SODIUM ION | non-polymer | 23.0 | 9 | Chemie (NA) PubChem (923) | |||
| 7 | L, U, V (A, D) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 8 | M, N (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 9 | AA, BA, CA, DA, W... (K, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) PubChem (24139) | |||
| 10 | EA, FA, GA, HA (B, C, D, G) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
G, K: 1 - 621 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Leu 622 | - | expression tag |
| Val 623 | - | expression tag |
| Pro 624 | - | expression tag |
| Arg 625 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 235691.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2198.1 | |
| All* | Total formula weight | 238314.3 |
