9Z4X
MENIN IN COMPLEX WITH JNJ-75276617 (Bleximenib)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Menin | polymer | 539 | 59790.0 | 4 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (human) | |
| 2 | E, J (A, B) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 2 | Chemie (BME) | |||
| 3 | F, K, O, Q (A, B, C, D) | N-ethyl-5-fluoro-2-{[5-(2-{(3R)-6-[(2-methoxyethyl)(methyl)amino]-2-methylhexan-3-yl}-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl]oxy}-N-(propan-2-yl)benzamide | non-polymer | 599.8 | 4 | Chemie (9N6) | |||
| 4 | G, L, P, R (A, B, C, D) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 5 | H, M, N (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | I (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 610 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| - | Glu 387 | deletion |
| - | Glu 388 | deletion |
| - | Arg 389 | deletion |
| - | Pro 390 | deletion |
| - | Gly 391 | deletion |
| - | Glu 392 | deletion |
| - | Gln 393 | deletion |
| - | Ser 394 | deletion |
| - | Gln 395 | deletion |
| - | Gly 396 | deletion |
| - | Thr 397 | deletion |
| - | Gln 398 | deletion |
| - | Arg 460 | deletion |
| - | Glu 461 | deletion |
| - | Ala 462 | deletion |
| - | Glu 463 | deletion |
| - | Ala 464 | deletion |
| - | Ala 465 | deletion |
| - | Glu 466 | deletion |
| - | Ala 467 | deletion |
| - | Glu 468 | deletion |
| - | Glu 469 | deletion |
| - | Pro 470 | deletion |
| - | Trp 471 | deletion |
| - | Gly 472 | deletion |
| - | Glu 473 | deletion |
| - | Glu 474 | deletion |
| - | Ala 475 | deletion |
| - | Arg 476 | deletion |
| - | Glu 477 | deletion |
| - | Gly 478 | deletion |
| - | Arg 479 | deletion |
| - | Arg 480 | deletion |
| - | Arg 481 | deletion |
| - | Gly 482 | deletion |
| - | Pro 483 | deletion |
| - | Arg 484 | deletion |
| - | Arg 485 | deletion |
| - | Glu 486 | deletion |
| - | Ser 487 | deletion |
| - | Lys 488 | deletion |
| - | Pro 489 | deletion |
| - | Glu 490 | deletion |
| - | Glu 491 | deletion |
| - | Pro 492 | deletion |
| - | Pro 493 | deletion |
| - | Pro 494 | deletion |
| - | Pro 495 | deletion |
| - | Lys 496 | deletion |
| - | Lys 497 | deletion |
| - | Pro 498 | deletion |
| - | Ala 499 | deletion |
| - | Leu 500 | deletion |
| - | Asp 501 | deletion |
| - | Lys 502 | deletion |
| - | Gly 503 | deletion |
| - | Leu 504 | deletion |
| - | Gly 505 | deletion |
| - | Thr 506 | deletion |
| - | Gly 507 | deletion |
| - | Gln 508 | deletion |
| - | Gly 509 | deletion |
| - | Ala 510 | deletion |
| - | Val 511 | deletion |
| - | Ser 512 | deletion |
| - | Gly 513 | deletion |
| - | Pro 514 | deletion |
| - | Pro 515 | deletion |
| - | Arg 516 | deletion |
| - | Lys 517 | deletion |
| - | Pro 518 | deletion |
| - | Pro 519 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 239159.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3019.7 | |
| All* | Total formula weight | 242179.6 |
