9Z4A
Cryo-EM structure of the human PRMT5:MEP50:pICln complex at a 4:3:4 stoichiometric ratio
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, D, G, J) | Protein arginine N-methyltransferase 5, N-terminally processed | polymer | 625 | 71805.5 | 4 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) | Homo sapiens (human) | |
| 2 | B, E, H (B, E, H) | Methylosome protein WDR77 | polymer | 307 | 33015.0 | 3 | UniProt (Q9BQA1) Pfam (PF00400) | Homo sapiens (human) | Androgen receptor cofactor p44,Methylosome protein 50,MEP-50,WD repeat-containing protein 77,p44/Mep50 |
| 3 | C, F, I, K (C, F, I, L) | Methylosome subunit pICln | polymer | 30 | 3364.5 | 4 | UniProt (P54105) | Homo sapiens (human) | Chloride channel,nucleotide sensitive 1A,Chloride conductance regulatory protein ICln,I(Cln),Chloride ion current inducer protein,ClCI,Reticulocyte pICln |
| 4 | L, M, N, O (A, D, G, J) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) PubChem (439155) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 399725.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1537.6 | |
| All* | Total formula weight | 401262.6 |
