9YZH

Crystal structure of HLA*02:01 with the 11-mer TP53 mutant peptide GLAPPQHLFRV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	MHC class I antigen	polymer	277	32082.5	2	UniProt (Q861F7)	Homo sapiens (human)
2	B, E (B, E)	Beta-2-microglobulin	polymer	100	11879.4	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)
3	C, F (C, F)	Peptide from Cellular tumor antigen p53	polymer	11	1236.5	2	UniProt (P04637)	Homo sapiens	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
4	G, H, J, K, M... (A, B, D, E)	1,2-ETHANEDIOL	non-polymer		62.1	8	Chemie (EDO)
5	I, L, Q (A, C, F)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL) PubChem (312)
6	R, S, T, U, V... (A, B, C, D, E...)	water	water		18.0	44	Chemie (HOH)

Sequence modifications

A, D: 1 - 276 (UniProt: Q861F7)

PDB	External Database	Details
Met 0	-	initiating methionine

B, E: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C, F: 187 - 197 (UniProt: P04637)

PDB	External Database	Details
Phe 195	Ile 195	variant

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	90396.7
Non-Polymers*	Number of molecules	11
	Total formula weight	602.9
All*	Total formula weight	90999.6

*Water molecules are not included.