9YWS

Human Sec61 complex bound to coibamide A

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Protein transport protein Sec61 subunit gamma	polymer	68	7752.3	1	UniProt (P60059) Pfam (PF00584)	Homo sapiens (human)
2	B (C)	Protein transport protein Sec61 subunit beta	polymer	96	9987.5	1	UniProt (P60468) Pfam (PF03911)	Homo sapiens (human)
3	C (A)	Protein transport protein Sec61 subunit alpha isoform 1	polymer	476	52202.4	1	UniProt (P61619) Pfam (PF10559) Pfam (PF00344)	Homo sapiens (human)	Sec61 alpha-1
4	D (D)	Coibamide A	polymer	11	1305.6	1		Leptolyngbya sp.
5	E (A)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR) PubChem (5997)

Sequence modifications

A: 1 - 476 (UniProt: P61619)

PDB	External Database	Details
Tyr 263	Val 263	engineered mutation
Glu 264	Asp 264	engineered mutation
Arg 268	Lys 268	engineered mutation
Thr 270	Ala 270	engineered mutation
Lys 271	Arg 271	engineered mutation
Val 272	Tyr 272	engineered mutation
Ile 276	Tyr 276	engineered mutation
Gly 277	Asn 277	engineered mutation
Ile 278	Thr 278	engineered mutation
Pro 387	Ala 387	engineered mutation
Arg 388	Lys 388	engineered mutation
Ile 390	Val 390	engineered mutation
Phe 394	Leu 394	engineered mutation
Asp 396	Glu 396	engineered mutation
Gly 398	Gln 398	engineered mutation
Ile 401	Met 401	engineered mutation
Asn 402	Arg 402	engineered mutation
Lys 404	His 404	engineered mutation
Ile 409	Met 409	engineered mutation
Tyr 410	Val 410	engineered mutation
Arg 411	His 411	engineered mutation
Lys 414	Asn 414	engineered mutation
Lys 415	Arg 415	engineered mutation
Ile 416	Tyr 416	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	71247.9
Non-Polymers*	Number of molecules	1
	Total formula weight	386.7
All*	Total formula weight	71634.5

*Water molecules are not included.