9YVL

Cryo-EM structure of the human TRPM4 channel in an open state bound to NC1 and PI(4,5)P2.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily M member 4	polymer	1231	136265.4	4	UniProt (Q8TD43)	Homo sapiens (human)	hTRPM4,Calcium-activated non-selective cation channel 1,Long transient receptor potential channel 4,LTrpC-4,LTrpC4,Melastatin-4
2	E, H, K, N (A, B, C, D)	[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate	non-polymer		1047.1	4	Chemie (PT5)
3	F, I, L, O (A, B, C, D)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA) PubChem (271)
4	G, J, M, P (A, B, C, D)	Necrocide 1	non-polymer		365.5	4	Chemie (A1CY8)

Sequence modifications

A, B, C, D: 2 - 1214 (UniProt: Q8TD43)

PDB	External Database	Details
Met -16	-	initiating methionine
Asp -15	-	expression tag
Tyr -14	-	expression tag
Lys -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
Gly -5	-	expression tag
Leu -4	-	expression tag
Val -3	-	expression tag
Pro -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	545061.4
Non-Polymers*	Number of molecules	12
	Total formula weight	5810.5
All*	Total formula weight	550872.0

*Water molecules are not included.