9YUZ
Structure of the human 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | Proteasome subunit alpha type-2 | polymer | 234 | 25927.5 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3 |
| 2 | B, P (B, P) | Proteasome subunit alpha type-4 | polymer | 261 | 29525.8 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L |
| 3 | C, Q (C, Q) | Proteasome subunit alpha type-7 | polymer | 248 | 27929.9 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7,Proteasome subunit alpha-4,alpha-4 |
| 4 | D, R (D, R) | Proteasome subunit alpha type-5 | polymer | 241 | 26436.0 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome subunit alpha-5,alpha-5,Proteasome zeta chain |
| 5 | E, S (E, S) | Proteasome subunit alpha type-1 | polymer | 263 | 29595.6 | 2 | UniProt (P25786) Pfam (PF00227) Pfam (PF10584) | Homo sapiens (human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain |
| 6 | F, T (F, T) | Proteasome subunit alpha type-3 | polymer | 255 | 28469.3 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8 |
| 7 | G, U (G, U) | Proteasome subunit alpha type-6 | polymer | 246 | 27432.5 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | 27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain |
| 8 | H, V (H, V) | Proteasome subunit beta type-7 | polymer | 277 | 30000.4 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z,Proteasome subunit beta-2,beta-2 |
| 9 | I, W (I, W) | Proteasome subunit beta type-3 | polymer | 205 | 22972.9 | 2 | UniProt (P49720) Pfam (PF00227) | Homo sapiens (human) | Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain |
| 10 | J, X (J, X) | Proteasome subunit beta type-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I |
| 11 | K, Y (K, Y) | Proteasome subunit beta type-5 | polymer | 263 | 28510.2 | 2 | UniProt (P28074) Pfam (PF00227) | Homo sapiens (human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X |
| 12 | L, Z (L, Z) | Proteasome subunit beta type-1 | polymer | 241 | 26522.4 | 2 | UniProt (P20618) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain |
| 13 | AA, M (M, a) | Proteasome subunit beta type-4 | polymer | 264 | 29231.2 | 2 | UniProt (P28070) Pfam (PF00227) | Homo sapiens (human) | 26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3 |
| 14 | BA, N (N, b) | Proteasome subunit beta type-6 | polymer | 239 | 25377.7 | 2 | UniProt (P28072) Pfam (PF00227) | Homo sapiens (human) | Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y |
| 15 | CA, DA (K, Y) | methyl N-{[(2R)-1-({(5R,8S)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate | non-polymer | 625.7 | 2 | Chemie (A1CY5) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 761591.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1251.5 | |
| All* | Total formula weight | 762842.8 |
