9YUF
PKR kinase domain - Dabrafenib complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interferon-induced, double-stranded RNA-activated protein kinase | polymer | 283 | 32550.5 | 4 | UniProt (B7ZKK7) | Homo sapiens (human) | Eukaryotic translation initiation factor 2-alpha kinase 2,Interferon-inducible RNA-dependent protein kinase,Protein kinase RNA-activated,Tyrosine-protein kinase EIF2AK2 |
| 2 | E, F, G, H (A, B, C, D) | Dabrafenib | non-polymer | 519.6 | 4 | Chemie (P06) PubChem (44462760) |
Sequence modifications
A, B, C, D: 258 - 540 (UniProt: B7ZKK7)
| PDB | External Database | Details |
|---|---|---|
| Ala 256 | - | expression tag |
| His 257 | - | expression tag |
| - | Asp 338 | deletion |
| - | Asp 339 | deletion |
| - | Ser 340 | deletion |
| - | Leu 341 | deletion |
| - | Glu 342 | deletion |
| - | Ser 343 | deletion |
| - | Ser 344 | deletion |
| - | Asp 345 | deletion |
| - | Tyr 346 | deletion |
| - | Asp 347 | deletion |
| - | Pro 348 | deletion |
| - | Glu 349 | deletion |
| - | Asn 350 | deletion |
| Asn 412 | His 412 | conflict |
| Asp 437 | Thr 437 | conflict |
| Thr 438 | Ser 438 | conflict |
| Lys 439 | Leu 439 | conflict |
| Gln 440 | Lys 440 | conflict |
| Val 441 | Asn 441 | conflict |
| Lys 442 | Asp 442 | conflict |
| Ile 443 | Gly 443 | conflict |
| Gly 444 | Lys 444 | conflict |
| Asp 445 | Arg 445 | conflict |
| Phe 446 | Thr 446 | conflict |
| Gly 447 | Arg 447 | conflict |
| Leu 448 | Ser 448 | conflict |
| Val 449 | Lys 449 | conflict |
| Thr 450 | Gly 450 | conflict |
| Lys 462 | Ser 462 | conflict |
| Gly 463 | Gln 463 | conflict |
| Lys 512 | - | insertion |
| Thr 513 | - | insertion |
| Leu 514 | - | insertion |
| Leu 515 | - | insertion |
| Gln 516 | - | insertion |
| Asn 541 | - | expression tag |
| Thr 542 | - | expression tag |
| Ser 543 | - | expression tag |
| Glu 544 | - | expression tag |
| Ile 545 | - | expression tag |
| Leu 546 | - | expression tag |
| Arg 547 | - | expression tag |
| Thr 548 | - | expression tag |
| Leu 549 | - | expression tag |
| Thr 550 | - | expression tag |
| Val 551 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130202.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2078.2 | |
| All* | Total formula weight | 132280.3 |
