9YRN
Cryo-EM structure of SARS-CoV-2 nsp10-nsp14 (E191A) in complex with T20P14-S complex, tetrameric form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, G, I (A, C, G, I) | Non-structural protein 10 | polymer | 139 | 14802.9 | 4 | UniProt (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | nsp10,Growth factor-like peptide,GFL |
| 2 | B, D, H, J (B, D, H, J) | Proofreading exoribonuclease | polymer | 527 | 59829.4 | 4 | UniProt (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14 |
| 3 | E, K (E, K) | T20P14-S RNA | polymer | 38 | 12187.3 | 2 | Severe acute respiratory syndrome coronavirus 2 | ||
| 4 | F, L (F, L) | P6 RNA | polymer | 6 | 1827.1 | 2 | Severe acute respiratory syndrome coronavirus 2 | ||
| 5 | AA, BA, DA, EA, FA... (G, H, I, J, A...) | ZINC ION | non-polymer | 65.4 | 20 | Chemie (ZN) | |||
| 6 | CA, IA, JA, O, U... (H, J, B, D) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 7 | NA, Z (K, E) | [(2~{R},3~{R},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | non-polymer | 340.2 | 2 | Chemie (K5X) |
Sequence modifications
B, D, H, J: 1 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 191 | Glu 6116 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 326558.3 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 2134.4 | |
| All* | Total formula weight | 328692.7 |
