9YQ8
Cryo-EM complex of meizothrombinDESF1, factor Xa, and factor Va
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Coagulation factor X | polymer | 344 | 38589.3 | 1 | UniProt (P00742) Pfam (PF14670) Pfam (PF00089) | Homo sapiens (human) | Stuart factor,Stuart-Prower factor |
| 2 | B (A) | Coagulation factor Va light chain | polymer | 651 | 75283.0 | 1 | UniProt (P12259) Pfam (PF07732) Pfam (PF00754) | Homo sapiens (human) | Activated protein C cofactor,Proaccelerin,labile factor |
| 3 | C (L) | Meizothrombin | polymer | 148 | 16503.9 | 1 | UniProt (P00734) Pfam (PF00051) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 4 | D (H) | Thrombin heavy chain | polymer | 257 | 29578.1 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 5 | E (B) | Coagulation factor V heavy chain | polymer | 674 | 77205.9 | 1 | UniProt (P12259) Pfam (PF07732) | Homo sapiens (human) | Activated protein C cofactor,Proaccelerin,labile factor |
Sequence modifications
E: 84 - 427 (UniProt: P00742)
H: 321 - 577 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 379 | Ser 419 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 525 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 237160.2 | |
| All* | Total formula weight | 237160.2 |
