9YOW
Crystal structure of GMPPNP bound KRAS G12C in complex with CYPA and RMC-4791
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Isoform 2B of GTPase KRas | polymer | 170 | 19374.9 | 2 | UniProt (P01116) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | C, D (D, B) | Peptidyl-prolyl cis-trans isomerase A | polymer | 166 | 18093.6 | 2 | UniProt (P62937) | Homo sapiens (human) | PPIase A,Cyclophilin A,Cyclosporin A-binding protein,Rotamase A |
| 3 | E, G (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 4 | F, H (A, C) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
| 5 | I, J (D, B) | 1-cyano-N-[(2S)-1-{[(1M,8S,10S,14S,21M)-22-ethyl-4-hydroxy-21-{2-[(1S)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]amino}-3-methyl-1-oxobutan-2-yl]-N-methylcyclopropane-1-carboxamide | non-polymer | 846.0 | 2 | Chemie (A1CYT) PubChem (156346949) | |||
| 6 | K, L, M, N (A, C, D, B) | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 169 (UniProt: P01116)
D, B: 1 - 165 (UniProt: P62937)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Lys 120 | Glu 120 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74937.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2785.1 | |
| All* | Total formula weight | 77722.1 |
