9YOT

Cryo-EM structure of an inactive dimer of the C. elegans EGFR (LET-23) extracellular region bound to LIN-3.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Receptor tyrosine-protein kinase let-23	polymer	799	91067.2	2	UniProt (P24348)	Caenorhabditis elegans	Lethal protein 23
2	B, D (C, D)	Protein spitz,Protein lin-3,Protein lin-3	polymer	104	11781.3	2	UniProt (Q03345)	Drosophila melanogaster (Fruit fly)	Abnormal cell lineage protein 3,Lethal protein 94
3	E, J (E, J)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB
4	F, G, I, K, L... (F, G, I, K, L...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB
5	H, M (H, M)	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB
6	O, P, Q, R (A, C, B, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B: 27 - 819 (UniProt: P24348)

PDB	External Database	Details
His 820	-	expression tag
His 821	-	expression tag
His 822	-	expression tag
His 823	-	expression tag
His 824	-	expression tag
His 825	-	expression tag

C, D: 103 - 147 (PDB: 9YOT)
C, D: 148 - 206 (UniProt: Q03345)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	205697.0
Branched	Number of molecules	10
	Total formula weight	5541.1
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	212123.0

*Water molecules are not included.