9YLB
Cryo-EM structure of single-loaded human UBA6-UBE2Z/FAT10(a) adenylate complex.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ubiquitin-like modifier-activating enzyme 6 | polymer | 1016 | 114475.9 | 1 | UniProt (A0AVT1) | Homo sapiens (human) | Ubiquitin-activating enzyme 6,Monocyte protein 4,MOP-4,Ubiquitin-activating enzyme E1-like protein 2,E1-L2 |
| 2 | B (B) | Ubiquitin-conjugating enzyme E2 Z | polymer | 262 | 29822.9 | 1 | UniProt (Q9H832) | Homo sapiens (human) | E2 ubiquitin-conjugating enzyme Z,Uba6-specific E2 conjugating enzyme 1,Use1,Ubiquitin carrier protein Z,Ubiquitin-protein ligase Z |
| 3 | C (C) | Ubiquitin D | polymer | 165 | 18476.5 | 1 | UniProt (A0A1U9X8S9) | Homo sapiens (human) | Diubiquitin,Ubiquitin-like protein FAT10 |
| 4 | D (A) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 5 | E (C) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) PubChem (6083) |
Sequence modifications
B: 93 - 354 (UniProt: Q9H832)
C: 1 - 165 (UniProt: A0A1U9X8S9)
| PDB | External Database | Details |
|---|---|---|
| Ser 100 | Cys 100 | engineered mutation |
| Ala 182 | Tyr 182 | engineered mutation |
| Ser 261 | Cys 261 | engineered mutation |
| Ser 263 | Cys 263 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Thr 7 | Cys 7 | engineered mutation |
| Thr 9 | Cys 9 | engineered mutation |
| Leu 134 | Cys 134 | engineered mutation |
| Ser 162 | Cys 162 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 162775.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1007.3 | |
| All* | Total formula weight | 163782.5 |
