9YIC
Crystal structure of human IL-17A in complex with Compound 1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interleukin-17A | polymer | 122 | 14209.9 | 4 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | E, F (A, C) | (3S)-N-[(3-{[(1S)-2-anilino-1-cyclohexyl-2-oxoethyl]carbamoyl}phenyl)methyl]-2,2-dimethylthiomorpholine-3-carboxamide | non-polymer | 522.7 | 2 | Chemie (A1CXF) | |||
| 3 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 12 - 132 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | - | initiating methionine |
| Gln 70 | Lys 93 | engineered mutation |
| Ser 106 | Cys 129 | engineered mutation |
| Gln 132 | Ala 155 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 56839.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1045.4 | |
| All* | Total formula weight | 57885.2 |
