9YGY
Structure of a GRP94 folding intermediate engaged with a CCDC134- and FKBP11-bound secretory translocon
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (5) | Translocon-associated protein subunit alpha | polymer | 286 | 32263.2 | 1 | UniProt (P43307) Pfam (PF03896) | Homo sapiens (human) | TRAP-alpha,Signal sequence receptor subunit alpha,SSR-alpha |
| 2 | B (6) | Translocon-associated protein subunit beta | polymer | 183 | 20155.0 | 1 | UniProt (P43308) Pfam (PF05753) | Homo sapiens (human) | TRAP-beta,Signal sequence receptor subunit beta,SSR-beta |
| 3 | C (7) | Translocon-associated protein subunit gamma | polymer | 185 | 21106.5 | 1 | UniProt (Q9UNL2) Pfam (PF07074) | Homo sapiens (human) | TRAP-gamma,Signal sequence receptor subunit gamma,SSR-gamma |
| 4 | D (8) | Translocon-associated protein subunit delta | polymer | 173 | 19015.5 | 1 | UniProt (P51571) Pfam (PF05404) | Homo sapiens (human) | TRAP-delta,Signal sequence receptor subunit delta,SSR-delta |
| 5 | E (A) | Peptidyl-prolyl cis-trans isomerase FKBP11 | polymer | 201 | 22213.4 | 1 | UniProt (Q9NYL4) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP11,19 kDa FK506-binding protein,19 kDa FKBP,FKBP-19,FK506-binding protein 11,FKBP-11,Rotamase |
| 6 | F (B) | Coiled-coil domain-containing protein 134 | polymer | 229 | 26598.6 | 1 | UniProt (Q9H6E4) Pfam (PF15002) | Homo sapiens (human) | |
| 7 | G (D) | Protein transport protein Sec61 subunit alpha isoform 1 | polymer | 476 | 52304.4 | 1 | UniProt (P61619) Pfam (PF10559) Pfam (PF00344) | Homo sapiens (human) | Sec61 alpha-1 |
| 8 | H (E) | Protein transport protein Sec61 subunit beta | polymer | 96 | 9987.5 | 1 | UniProt (P60468) Pfam (PF03911) | Homo sapiens (human) | |
| 9 | I (F) | Protein transport protein Sec61 subunit gamma | polymer | 68 | 7752.3 | 1 | UniProt (P60059) Pfam (PF00584) | Homo sapiens (human) | |
| 10 | J (G) | Stress-associated endoplasmic reticulum protein 1 | polymer | 66 | 7384.8 | 1 | UniProt (Q9Y6X1) Pfam (PF06624) | Homo sapiens (human) | Ribosome-attached membrane protein 4 |
| 11 | K (I) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A | polymer | 705 | 80607.3 | 1 | UniProt (P46977) Pfam (PF02516) Pfam (PF22627) | Homo sapiens (human) | Oligosaccharyl transferase subunit STT3A,STT3-A,B5,Integral membrane protein 1,Transmembrane protein TMC |
| 12 | L (J) | Oligosaccharyltransferase complex subunit OSTC | polymer | 149 | 16844.2 | 1 | UniProt (Q9NRP0) Pfam (PF04756) | Homo sapiens (human) | Hydrophobic protein HSF-28 |
| 13 | M (K2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 | polymer | 37 | 4196.0 | 1 | UniProt (P0C6T2) Pfam (PF10215) | Homo sapiens (human) | |
| 14 | N (L2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258 | polymer | 79 | 9083.8 | 1 | UniProt (P61165) Pfam (PF05251) | Homo sapiens (human) | Oligosaccharyl transferase subunit TMEM258,Transmembrane protein 258 |
| 15 | O (M2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 | polymer | 113 | 12503.6 | 1 | UniProt (P61803) Pfam (PF02109) | Homo sapiens (human) | Oligosaccharyl transferase subunit DAD1,Defender against cell death 1,DAD-1 |
| 16 | P (N) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 | polymer | 136 | 14689.5 | 1 | UniProt (Q8N6L1) Pfam (PF09775) | Homo sapiens (human) | Oligosaccharyl transferase subunit KCP2,Keratinocyte-associated protein 2,KCP-2 |
| 17 | Q (N2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit | polymer | 456 | 50854.6 | 1 | UniProt (P39656) Pfam (PF03345) Pfam (PF23358) | Homo sapiens (human) | DDOST 48 kDa subunit,Oligosaccharyl transferase 48 kDa subunit |
| 18 | R (O2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | polymer | 607 | 68656.2 | 1 | UniProt (P04843) Pfam (PF04597) | Homo sapiens (human) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit,Ribophorin I,RPN-I,Ribophorin-1 |
| 19 | S (P2) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 | polymer | 631 | 69347.5 | 1 | UniProt (P04844) Pfam (PF05817) Pfam (PF23861) Pfam (PF23860) Pfam (PF25147) | Homo sapiens (human) | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit,RIBIIR,Ribophorin II,RPN-II,Ribophorin-2 |
| 20 | T (y3) | Endoplasmin | polymer | 846 | 96254.2 | 1 | UniProt (P14625) Pfam (PF13589) Pfam (PF00183) | Homo sapiens (human) | 94 kDa glucose-regulated protein,GRP-94,Heat shock protein 90 kDa beta member 1,Heat shock protein family C member 4,Tumor rejection antigen 1,gp96 homolog |
| 21 | U (K) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 22 | V (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 23 | W (H) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G81980VO) | |||
| 24 | X (L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G05026ZL) | |||
| 25 | Y (I) | phosphono [(3~{R},6~{E},10~{E})-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl] hydrogen phosphate | non-polymer | 452.5 | 1 | Chemie (ELU) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 641818.1 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3643.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 452.5 | |
| All* | Total formula weight | 645913.9 |
