9YGO

HuCoV-HKU1 C S 2P in complex with H501-018 Fab (State 2, global cryoEM)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Spike glycoprotein	polymer	1334	148411.5	3	UniProt (Q0ZME7)	Human coronavirus HKU1 (isolate N5)	S glycoprotein,E2,Peplomer protein
2	D, E, F (H, I, J)	H501-018 Fab heavy chain	polymer	224	23925.9	3		Homo sapiens
3	G, H, I (L, M, N)	H501-018 Fab light chain	polymer	216	22995.4	3		Homo sapiens
4	J (K)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	AA, BA, CA, DA, EA... (C, A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	22	Chemie (NAG) PubChem (24139)

Sequence modifications

A, B, C: 1 - 1277 (UniProt: Q0ZME7)

PDB	External Database	Details
Gly 752	Arg 752	engineered mutation
Gly 753	Arg 753	engineered mutation
Ser 754	Lys 754	engineered mutation
Gly 755	Arg 755	engineered mutation
Ser 756	Arg 756	engineered mutation
Pro 1067	Asn 1067	engineered mutation
Pro 1068	Leu 1068	engineered mutation
Gly 1278	-	expression tag
Arg 1279	-	expression tag
Leu 1280	-	expression tag
Glu 1281	-	expression tag
Val 1282	-	expression tag
Leu 1283	-	expression tag
Phe 1284	-	expression tag
Gln 1285	-	expression tag
Gly 1286	-	expression tag
Pro 1287	-	expression tag
Gly 1288	-	expression tag
Gly 1289	-	expression tag
Tyr 1290	-	expression tag
Ile 1291	-	expression tag
Pro 1292	-	expression tag
Glu 1293	-	expression tag
Ala 1294	-	expression tag
Pro 1295	-	expression tag
Arg 1296	-	expression tag
Asp 1297	-	expression tag
Gly 1298	-	expression tag
Gln 1299	-	expression tag
Ala 1300	-	expression tag
Tyr 1301	-	expression tag
Val 1302	-	expression tag
Arg 1303	-	expression tag
Lys 1304	-	expression tag
Asp 1305	-	expression tag
Gly 1306	-	expression tag
Glu 1307	-	expression tag
Trp 1308	-	expression tag
Val 1309	-	expression tag
Leu 1310	-	expression tag
Leu 1311	-	expression tag
Ser 1312	-	expression tag
Thr 1313	-	expression tag
Phe 1314	-	expression tag
Leu 1315	-	expression tag
Gly 1316	-	expression tag
His 1317	-	expression tag
His 1318	-	expression tag
His 1319	-	expression tag
His 1320	-	expression tag
His 1321	-	expression tag
His 1322	-	expression tag
His 1323	-	expression tag
His 1324	-	expression tag
Ser 1325	-	expression tag
Ala 1326	-	expression tag
Trp 1327	-	expression tag
Ser 1328	-	expression tag
His 1329	-	expression tag
Pro 1330	-	expression tag
Gln 1331	-	expression tag
Phe 1332	-	expression tag
Glu 1333	-	expression tag
Lys 1334	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	585998.5
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	22
	Total formula weight	4866.6
All*	Total formula weight	591289.5

*Water molecules are not included.