9YG3
Targeting PTPN22 at non-orthosteric binding sites - a fragment approach
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 22 | polymer | 309 | 36500.8 | 2 | UniProt (Q9Y2R2) Pfam (PF00102) | Homo sapiens (human) | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP,Lymphoid phosphatase,LyP,PEST-domain phosphatase,PEP |
| 2 | C, E (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | D, G (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | F (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 390 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 303 (UniProt: Q9Y2R2)
| PDB | External Database | Details |
|---|---|---|
| His 304 | - | expression tag |
| His 305 | - | expression tag |
| His 306 | - | expression tag |
| His 307 | - | expression tag |
| His 308 | - | expression tag |
| His 309 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73001.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 194.4 | |
| All* | Total formula weight | 73196.0 |
