9YFU
Structure of GPR61 bound to inverse agonist compound 15
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | G-protein coupled receptor 61,Soluble cytochrome b562 | polymer | 542 | 59860.7 | 1 | UniProt (Q9BZJ8) UniProt (P0ABE7) | Homo sapiens (human) | Biogenic amine receptor-like G-protein coupled receptor,Cytochrome b-562 |
| 2 | B (H) | Fab24 BAK5 heavy chain | polymer | 226 | 24021.8 | 1 | Homo sapiens | ||
| 3 | C (N) | Hinge-binding nanobody | polymer | 135 | 14957.3 | 1 | Lama glama | ||
| 4 | D (C) | Fab24 BAK5 light chain | polymer | 264 | 28884.6 | 1 | Homo sapiens | ||
| 5 | E (R) | N-(5-chloro-4,6-dimethylpyrimidin-2-yl)-6-{[(3,5-difluoropyridin-4-yl)methyl]amino}-2-methylpyridine-3-sulfonamide | non-polymer | 454.9 | 1 | Chemie (A1CWB) | |||
| 6 | F (R) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
R: 2 - 233 (UniProt: Q9BZJ8)
R: 239 - 343 (UniProt: P0ABE7)
R: 351 - 518 (UniProt: Q9BZJ8)
| PDB | External Database | Details |
|---|---|---|
| Tyr -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Val -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Tyr 0 | - | expression tag |
| Ala 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 245 | Met 29 | conflict |
| Ile 340 | His 124 | conflict |
| Leu 344 | - | linker |
| Glu 345 | - | linker |
| Arg 345 | - | linker |
| Ala 345 | - | linker |
| Arg 345 | - | linker |
| Ser 345 | - | linker |
| Thr 345 | - | linker |
| Leu 345 | - | linker |
| Gln 345 | - | linker |
| Lys 345 | - | linker |
| Glu 345 | - | linker |
| Val 345 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 234 | - | linker |
| Arg 235 | - | linker |
| Arg 236 | - | linker |
| Gln 237 | - | linker |
| Leu 238 | - | linker |
| Gly 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Asp 521 | - | expression tag |
| Tyr 522 | - | expression tag |
| Lys 523 | - | expression tag |
| Asp 524 | - | expression tag |
| Asp 525 | - | expression tag |
| Asp 526 | - | expression tag |
| Asp 527 | - | expression tag |
| Ala 528 | - | expression tag |
| Lys 529 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127724.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 454.9 | |
| All* | Total formula weight | 128179.3 |
