9YEM
Cryo-EM structure of triple-bound FDG antibody VRC49.01 in complex with HIV-1 Env BG505 DS-SOSIP trimer
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, M (A, B, I) | BG505 SOSIP.664 gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S5) | Human immunodeficiency virus 1 | |
| 2 | B, H, N (C, D, J) | BG505 SOSIP.664 gp120 | polymer | 480 | 53929.1 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | |
| 3 | C, E, I, K, O... (K, M, E, G, O...) | VRC49.01 Heavy | polymer | 125 | 13690.3 | 6 | Homo sapiens | ||
| 4 | D, F, J, L, P... (L, N, F, H, P...) | VRC49.01 Light | polymer | 107 | 11691.1 | 6 | Homo sapiens | ||
| 5 | AA, CA, EA, FA, GA... (a, c, e, f, g...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 18 | In PDB GlyTouCan (G42666HT) | |||
| 6 | DA, NA, T (d, n, T) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G56014GC) | |||
| 7 | BA, IA, LA, SA, VA... (b, i, l, s, v...) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 6 | In PDB GlyTouCan (G83161QT) | |||
| 8 | JA, TA, Z (j, t, Z) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 9 | AB, AC, BB, BC, CB... (C, J, B, D, I...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 33 | Chemie (NAG) PubChem (24139) |
Sequence modifications
A, B, I: 512 - 664 (UniProt: Q2N0S5)
C, D, J: 31 - 512 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | engineered mutation |
| Cys 605 | Thr 602 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 201 | Ile 200 | conflict |
| Asn 332 | Thr 330 | conflict |
| Cys 433 | Ala 430 | conflict |
| Cys 501 | Ala 498 | conflict |
| Arg 509 | Glu 506 | conflict |
| Arg 510 | Lys 507 | conflict |
| Arg 512 | Ala 509 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 365515.0 | |
| Branched | Number of molecules | 30 |
| Total formula weight | 21974.1 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 7299.9 | |
| All* | Total formula weight | 394788.9 |
