9YDP

Human delta opioid receptor complex with mini-Gi and agonist DADLE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	polymer	245	27915.7	1		Homo sapiens (human)
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	350	38534.1	1	UniProt (P62873) Pfam (PF00400)	Homo sapiens (human)	Transducin beta chain 1
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
4	D (N)	nanobody 35	polymer	156	16926.1	1		Lama glama
5	E (R)	Delta-type opioid receptor	polymer	387	42363.5	1	UniProt (P41143) Pfam (PF00001)	Homo sapiens (human)	D-OR-1,DOR-1
6	F (P)	DADLE	polymer	5	569.6	1		Homo sapiens
7	G, H, I, J, K... (A, B, G, N, R...)	water	water		18.0	93	Chemie (HOH)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

R: 2 - 372 (UniProt: P41143)

PDB	External Database	Details
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Ala 1	-	expression tag
Phe 27	Cys 27	conflict
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag
His 379	-	expression tag
His 380	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	134170.1
All*	Total formula weight	134170.1

*Water molecules are not included.