9YC0
Plasmodium falciparum M17 aminopeptidase (PfA-M17) bound to inhibitor 3ab (MIPS3413)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | M17 leucyl aminopeptidase | polymer | 527 | 58577.8 | 12 | UniProt (Q8IL11) Pfam (PF00883) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 2 | CC, DA, DC, EA, FD... (E, B, G, I, L...) | ZINC ION | non-polymer | 65.4 | 24 | Chemie (ZN) | |||
| 3 | EC, FA, HD, JE, LG... (E, B, G, I, L...) | CARBONATE ION | non-polymer | 60.0 | 12 | Chemie (CO3) | |||
| 4 | BB, CB, EF, FC, FF... (C, J, E, B, G...) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 36 | Chemie (PEG) | |||
| 5 | AA, AD, AG, BD, BE... (A, F, K, H, J...) | SULFATE ION | non-polymer | 96.1 | 59 | Chemie (SO4) | |||
| 6 | AB, DF, JC, KA, OE... (C, J, E, B, I...) | N-[(1R)-1-(1,3-benzothiazol-5-yl)-2-(hydroxyamino)-2-oxoethyl]-3,3-dimethylbutanamide | non-polymer | 321.4 | 11 | Chemie (A1CT4) | |||
| 7 | AC, BA, BF, CA, DD... (D, A, J, F, K...) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 37 | Chemie (1PE) | |||
| 8 | AE, AF, BC, DB, GF... (H, J, D, C, B...) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 13 | Chemie (DMS) | |||
| 9 | GE, QA (H, B) | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 2 | Chemie (2PE) | |||
| 10 | JD (G) | N-[(1S)-1-(1,3-benzothiazol-5-yl)-2-(hydroxyamino)-2-oxoethyl]-3,3-dimethylbutanamide | non-polymer | 321.4 | 1 | Chemie (A1CT5) | |||
| 11 | AH, BH, CH, DH, EH... (B, C, D, E, F...) | water | water | 18.0 | 3492 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 85 - 605 (UniProt: Q8IL11)
| PDB | External Database | Details |
|---|---|---|
| Gln 152 | Asn 152 | engineered mutation |
| Gln 515 | Asn 515 | engineered mutation |
| Gln 546 | Asn 546 | engineered mutation |
| His 606 | - | expression tag |
| His 607 | - | expression tag |
| His 608 | - | expression tag |
| His 609 | - | expression tag |
| His 610 | - | expression tag |
| His 611 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 702933.3 | |
| Non-Polymers* | Number of molecules | 195 |
| Total formula weight | 26295.7 | |
| All* | Total formula weight | 729229.0 |
