9Y9N
PLK4 in complex with Compound 25 ((R)-7-hydroxy-N-(3-(1-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1H-pyrazol-4-yl)-7-(trifluoromethyl)-4-azaspiro[2.5]octane-4-carboxamide)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK4 | polymer | 266 | 30530.4 | 1 | UniProt (O00444) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 4,PLK-4,Serine/threonine-protein kinase 18,Serine/threonine-protein kinase Sak |
| 2 | B (A) | (7R)-7-hydroxy-N-{(5P)-5-[1-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-1H-pyrazol-4-yl}-7-(trifluoromethyl)-4-azaspiro[2.5]octane-4-carboxamide | non-polymer | 503.4 | 1 | Chemie (A1CTV) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 4 - 269 (UniProt: O00444)
| PDB | External Database | Details |
|---|---|---|
| Asp 170 | Thr 170 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30530.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 599.5 | |
| All* | Total formula weight | 31129.8 |
