9Y9B
PLK4 in complex with Compound 6 (3-hydroxy-N-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK4 | polymer | 278 | 31723.7 | 1 | UniProt (O00444) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 4,PLK-4,Serine/threonine-protein kinase 18,Serine/threonine-protein kinase Sak |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C (A) | (1R,3r,5S)-3-hydroxy-N-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-8-azabicyclo[3.2.1]octane-8-carboxamide | non-polymer | 313.4 | 1 | Chemie (A1CTX) | |||
| 4 | D (A) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 2 - 275 (UniProt: O00444)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Glu 276 | - | expression tag |
| Gly 277 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31723.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 409.4 | |
| All* | Total formula weight | 32133.1 |
