9Y76
Crystal structure of the human DCAF1 WDR domain in complex with OICR-40120
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DDB1- and CUL4-associated factor 1 | polymer | 315 | 35592.9 | 2 | UniProt (Q9Y4B6) | Homo sapiens (human) | HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein |
| 2 | C, E (A, B) | (4P,5M)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-{1-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-4-yl}-1H-pyrrole-3-carboxamide | non-polymer | 617.5 | 2 | Chemie (A1CSX) | |||
| 3 | D (A) | UNKNOWN LIGAND | non-polymer | 18.0 | 1 | Chemie (UNX) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence modifications
A, B: 1077 - 1390 (UniProt: Q9Y4B6)
| PDB | External Database | Details |
|---|---|---|
| Gly 1076 | - | expression tag |
| Ala 1077 | Phe 1077 | engineered mutation |
| Ala 1079 | Arg 1079 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71185.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1253.0 | |
| All* | Total formula weight | 72438.9 |
